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Meditation on Death in Mary Oliver's Poetry
(2010) Giri, Anita; Maheshwor Paudel
This research examines the images of death in Mary Oliver's poetry. Meditation on death is the motif behind this research. As we know, there is co-relation between life and death, where there is life; it's sure and certain that there is death. Oliver's most of the poems are related to death. A number of her poems have the word death occurring in them and there are terms linked with the effects of death, silence, grave, funeral, and tomb. Time and again she has imagined her own death, or of poetic persona, or the death of any other character in her poetry. Her death poems give the glimpse of life poems. Except death nothing is beautiful for her. Whatever position human beings acquire in the society is nothing for her because one day everyone should die. In most of her poetry, she is searching her existence in death. Nothingness is the goal of her life. Death is a certainty among innumerable uncertainties of life. Death is the gateway to achieve freedom in her life and it is the essential factor in her poetry.
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Collaboration of mobile commerce and mobile GIS
(2007) Joshi, Dipesh Man; Min Bahadur Karki
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Prospects of indole derivatives as methyl transfer inhibitors: amr managers
(2018) Jha, Suprim; Pramod Aryal
It is prudent that new antibiotics be urgently developed as to manage WHO listed critical and high priority nine multi-drug resistant (MDR) pathogens posing unprecedented medical crisis. Simultaneously, multiple essential proteins have to be targeted to prevent easy resistance development. Whole genome sequences of these pathogens were aligned exploiting DNA alignment potential of MAUVE software to identify putative common lead target proteins in all nine pathogens. S-adenosyl methionine (SAM), a critical metabolite in several biochemical reactions, biosynthesizing metK gene was taken as the lead target and the gene essentiality analysis using COBRA tool revealed that SAM is a critical metabolite. Furthermore, gene essentiality of corrin methylation steps revealed cobA gene as essential. Hence, from the library of 715 indole derivatives, chosen based on kinase inhibition potential of some indoles, around 102 were pursued based on ADME/T scores. Among these, the 58 higher binding derivatives against N. gonorrhoea MetK were further expanded to MetK proteins of all nine pathogens and 9 derivatives exhibited higher binding energy. These, 58 upon docking to other SAM utilizing enzymes, CobA, CysG, Dam, TrmD and cis regulatory RNA SAM-I riboswitch, 8 derivatives had higher binding energy and six had multi-target including MetK in all pathogens. Further, docking with human metK homologue showed 1-Methyl-3,4-bis(3indolyl) maleimide as the only drug candidate with minimal effects on human but inhibitory effects on all studied targets. The molecule could be developed to treat infections caused by N. gonorrhoea, A. baumanii, C. coli, K. pneumoniae, E. faecium, H. pylori, P. aeruginosa, S. aureus and S. typhii. Key words: In silico virtual screening, WHO priority pathogens, drug resistance, putative antimicrobials, Indole