Seroprevalence of Hepatitis C and HIV Among Blood Donors in kathmandu Valley

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Department of Microbiology

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During the study period of December 1st 2006 to September 1st 2007,a total of 33,255 blood donors in Kathmandu Valley were screened for Anti HCV antibodies and AntiHIV-1 and 2 antibodies using third generation ELISA kits and automated ELISA Processor(BEP III)in Serology Laboratory of NRCS, CBTS. The seroprevalence of hepatitis C was observed 0.66%,more in Volunteer donors(0.69%) than in Replacement donors (0.4%) (P < 0.05). In male donors these roprevalence was 0.7% and in female donors it was 0.39%(P < 0.05).Surprisingly,the seroprevalence was almost similar in first time(0.65%) and repeat donors(0.67%)(P>0.05). HCV was found to be most prevalent(0.82%) in age group of 21-30years (P<0.05), in males it was most prevalent(0.88%) in age group of 21-30 years (P < 0.05)and in females it was most prevalent(0.47%) in the age group of 41-50years(P > 0.05).The seroprevalence of HIV wasobserved0.19%, more in Volunteer donors(0.2%) than in Replacement donors(0.13%)(P>0.05).In male donors the seroprevalence was 0.2%and in female donors it was 0.16%(P>0.05).The seroprevalence was almost similar in first time(0.2%) and repeat donors(0.19%)(P>0.05).The seroprevalence of HIV was found to be highest(0.24%) in age group of21-30years inmale donors(P>0.05) and in female do norsit was highest(0.23%) in age group of41-50years(P>0.05). The coprevalence of HCV and HIV was observed 0.02%.HCV coprevalence was observed in 10.76% of HIV seropositive donors whereas HIV coprevalence was observed in 3.16% of HCV seropositive donors. HCV and HIV seropositivity was associated with each other (P<0.05). Hence, HCV and HIV seroprevalence among blood donors in Kathmandu Valley was0.66% and 0.19% respectively. Key words: HCV, HIV, Seroprevalence, Coprevalence, Blood donors

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