Prevalence and Antimicrobial Susceptibility Profile of Acinetobacter Spp in Kathmandu Medical College, Sinamangal, Nepal
Date
2012
Authors
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Journal ISSN
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Publisher
Department of Microbiology
Abstract
Acinetobacter spp. is emerging as a greater threat and challenge worldwide due
to its high prevalence and ability to acquire antimicrobial drug resistance by all
known modes of mechanisms that is variable in different countries, regions,
hospitals and even different wards. Hence, local surveillance based on local
scenario of Acinetobacter is mandatory for the selection of proper therapeutic
options by the clinicians. This study has the objective to determine the overall
prevalence and antimicrobial susceptibility profile of Acinetobacter spp. and
was out carried at Kathmandu Medical College, Sinamangal, Nepal from
October 2009 to March 2010. In this study, Conventional bacteriological
methods were used for the identification of Acinetobacter spp. and
susceptibility testing was performed by disk-diffusion method recommended
by Clinical Laboratory Standard Institute (CLSI).
The overall prevalence of Acinetobacter spp. was 9.1% out of 810 total
bacterial isolates and 10.4% out of total 713 gram-negative isolates that was
higher in males (52.7%) than in females (47.3%) of age-group 20-40 years and
highest in intensive care units (72.2%) among different wards. Among isolates
from different types of specimens, the prevalence of Acinetobacter spp. was
found to highest in miscellaneous specimens followed by catheter tips and
respiratory tract specimens. Out of 24 antimicrobial drugs used against all
Acinetobacter spp., Carbapenems, Ceftriaxone, Co-trimoxazole,
Cefoperazone/sulbactam and Chloramphenicol were the most effective
antimicrobials in this hospital.
In conclusion, the prevalence of Acinetobacter spp in Kathmandu Medical
College was higher in male patients of age groups (20-40) year and in intensive
care units (ICUs) in miscellaneous specimens followed by catheter tips and
respiratory tract specimens. Carbapenems, Ceftriaxone, and Co-trimazole were
the most effective antimicrobials against Acinetobacter spp. in this hospital.
Key words: Acinetobacter, prevalence, susceptibility profile, Carbapenems,
Ceftriaxone, Co-trimoxaxole
Description
Keywords
Acinetobacter, Susceptibility profile, Ceftriaxone, Co-trimoxaxole