Study on Incidence of Nalidixic Acid Resistant Salmonella Enterica Serovar Typhi and Salmonella Entrica Serovar Paratyphi A and Their Antibiotic Susceptibilities
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Department of Microbiology
Abstract
A total of 949 blood specimen from patients suspected of enteric fever
were included in this study. Among them 66 (6.95 percent) blood
specimen were culture positive. The incidence of S. Typhi and S.
Paratyphi A among total suspected enteric fever patient was 3.2% (30)
and 3.8% (36) respectively. The incidence of culture positive case was
highest among the age group of 10-20 years (12.4%). Among 66 culture
positive cases, the incidence rate was more in male patient (8.9%) than
female patient (4.7%).The culture positive rate was found maximum
from out patients (7.5%) than inpatients (5.4%). The incidence of
Nalidixic acid resistant Salmonella isolates among outpatient and
inpatient was 7.2% and 4.6% respectively. The incidence of Nalidixic
acid resistant S.Typhi and S. Paratyphi A among total population was
2.7% and 3.8% respectively. The incidence of Nalidixic acid resistant
Salmonella isolates among male and female was 8.1% and 4.7%
respectively. Among 66 isolates, 30 (45.5%) were Salmonella Typhi
and 36 (54.5%) were Salmonella Paratyphi A.
The most sensitive antibiotics for Salmonella Typhi were found to be
ciprofloxacin and ceftriaxone. Similarly the most sensitive antibiotics
for Salmonella Paratyphi A were found to be ciprofloxacin, ceftriaxone,
cotrimoxazole and chloramphenicol.
Among 62 Nalidixic acid resistant isolates 26(41.94%) were
Salmonella Typhi and 36 (58.1%) were Salmonella Paratyphi A. In
contrast, among 4 Nalidixic acid susceptible isolates all 4 (100%) were
Salmonella Typhi and non were Salmonella Paratyphi A.
In this study, none of the nalidixic acid resistance isolates were found
Ciprofloxacin resistance.
Key words: Enteric fever, Salmonella, Nalidixic acid resistance