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https://elibrary.tucl.edu.np/handle/123456789/9328
Title: | Prevalence of Bacterial and Fungal Agents Causing Lower Respiratory Tract Infections in Patients with Human Immunodeficiency Virus (Hiv) Infection |
Authors: | Dahal, Sanchita |
Keywords: | HIV infection;Bacterial pathogen |
Issue Date: | 2006 |
Publisher: | Department of Microbiology |
Institute Name: | Central Department of Microbiology |
Level: | Masters |
Abstract: | Present study was carried out to study the prevalence of bacterial and fungal agents causing lower respiratory tract infection in HIV infected individuals. LRTI is a common problem among HIV positive patients and majority are due to bacterial infections. A total of 120 HIV infected individuals were included in this study. Gram stain, Ziehl-Neelsen stain and sputum culture were performed. The pattern of microbial distribution on direct microscopic examination was: Gram-positive bacteria-19, Gram-negative bacteria-37, AFB-6 and fungal isolates-36. Sixty-five percent samples showed growth of different bacteria in different culture media. Among them K. pneumoniae (28.6%) was most frequently isolated bacterial pathogen followed by E. coli (17.9%), S. pneumoniae (17.9%), S. aureus (16.1%), AFB (5.0%), P. aeruginosa (8.9%), M. catarrhalis (7.0%) and H. influenzae (3.6%). Among fungal pathogens, most frequently isolated was Candida albicans (44.4%), Aspergillus spp (30.6%) and Penicillium spp (8.3%). Antibiotic susceptibility pattern was examined for bacterial isolates. Among Gram negative bacteria, K. pneumoniae was most sensitive towards chloramphenicol (62.5%) whereas least sensitive towards co-trimoxazole (37.5%). E. coli showed 60% sensitivity towards chloramphenicol and gentamicin whereas 20% sensitivity towards ampicillin. P. aeruginosa was most sensitive towards gentamicin (60%) and least sensitive towards chloramphenicol. M. catarrhalis showed 50% sensitivity towards chloramphenicol, co-trimoxazole and gentamicin whereas 25% sensitivity towards ampicillin and tetracycline. H. influenzae showed 50% sensitivity towards chloramphenicol, ampicillin, gentamicin and tetracycline whereas least sensitive towards co-trimoxazole. S. pneumoniae showed 50% sensitivity towards chloramphenicol, gentamicin and tetracycline whereas 20% sensitivity towards ampicillin. S. aureus showed 55.5% sensitivity towards chloramphenicol, gentamicin,and tetracycline whereas 22.2% sensitivity towards ampicillin. Polymicrobial isolation was also observed. Pneumocystis carinii pneumonia was not documented in our stu |
URI: | https://elibrary.tucl.edu.np/handle/123456789/9328 |
Appears in Collections: | Microbiology |
Files in This Item:
File | Description | Size | Format | |
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fULL thesis.pdf | 416.52 kB | Adobe PDF | View/Open |
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