Comparative Analysis of G6PD Deficiency Between Dagaura Tharu and Rana Tharu in Laljhadi Rural Municipality of Kanchanpur Distric, Nepal

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme that has a housekeeping role in all cells and is particularly critical to the functioning of red blood cells (RBCs). When G6PD activity is deficient, they have a diminished ability to withstand stress, and therefore risk (hemolysis). The large majority of G6PD deficient subjects have no clinical manifestations and the condition remains asymptomatic until they are exposed to a hemolytic trigger. The objective of this study was to compare the analysis of G6PD deficiency between Dagaura Tharu and Rana Tharu in Laljhadi Rural Municipality of Kanchanpur district in Nepal. Whole blood samples of sample size 300 were collected from those indigenous people of Laljhadi Rural Municipality of Kanchanpur district in Nepal during April 8 to May 18 2018. All collected blood samples were tested by using Formazan Ring Method. Out of 300 test cases, the G6PD deficiency by using Formazan Ring Method was found to be 24(8%). The G6PD deficiency by using Formazan Ring Method was found to be 15(10%) in Dagaura Tharu and 9(6%) in Rana Tharu. Out of 24 G6PD deficient cases, 19(79.16%) were male G6PD deficient and 5(20.83%) were female G6PD deficient. All of the deficient cases were from ethnic communities who were the inhabitants of malaria endemic areas. Primaquine is the key drug for malaria treatment. On such persons who have G6PD deficiency, this drug causes the RBC haemolysis. So Primaquine should be administered only after the testing of G6PD especially in the ethnic groups.